(from the December 2023 Annals for Educators)
The association between treatment of acute COVID-19 with nirmatrelvir–ritonavir (N-R) and virologic rebound (VR) is uncertain. This observational cohort study in a multicenter health care system compared the frequency of VR in patients who received 5 days of N-R treatment versus those who received no COVID-19 therapy. The accompanying editorial discusses the findings and emphasizes the need for further consideration of the dosage, timing, and duration of treatment to inform optimal use of N-R.
Use this and the to:
- Review the indications for treatment of COVID-19 with N-R. can help guide you.
- Think about patients you've had who have experienced rebound after treatment of COVID-19 with N-R.
- How do you best advise patients who experience rebound?
- What are the strengths and limitations of this observational study? The editorial will help guide you.
- Think about how you would design a study that could more definitively define the risk for and consequences of rebound in this setting.
Annals for Educators is a Web Exclusives feature of Annals of Internal Medicine which includes activities using selected Annals articles to help medical educators in their teaching activities.
Back to the January 2024 issue of ACP IMpact